Welcome to the Coster Lab!

Based in the Institute of Cancer Research in London, we study how our genome is replicated accurately and efficiently

Our Research

We are interested in revealing the factors and mechanisms that underpin accurate chromosomal replication.

We use a powerful combination of in-vitro biochemistry, genetics, cell biology, proteomics and structural biology.

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Affiliation

We are part of the Cell and Molecular Biology division within the Institute of Cancer Research.

ICR

We are located in the heart of London, in the Royal Borough of Kensington and Chelsea.

Contact us

Dr. Gideon Coster

2011 – Ph.D. in Genetics with Prof. Michal Goldberg. Hebrew University of Jerusalem, Israel.
2004 – B.Sc. in Life Sciences, “Amirim” and “Etgar” special programs for outstanding Natural Sciences and Life Sciences students. Hebrew University of Jerusalem, Israel.

2018 – present – Tenured Reader (=Associate Professor), Group Leader and Wellcome Trust Fellow, Division of Cell and Molecular Biology, ICR, London, UK.
2011 – 2018 – Postdoctoral fellow with Dr. John Diffley. The Francis Crick Institute, London, UK (formerly CR-UK London Research Institute, Clare Hall Labs).
2004 – 2010 – Teaching Assistant, Course #72301 “Introduction to Probability and Statistics”, Hebrew University of Jerusalem, Israel.
2005 – 2007 – Elected Chairman, Union of Teaching Assistants, Hebrew University of Jerusalem, Israel.

2018 – Wellcome Trust and Royal Society Sir Henry Dale Fellowship
2018 – Cancer Research UK Career Development Fellowship (respectfully declined)
2011 – Menashe Marcus Prize for outstanding PhD students, Genetics Department, Hebrew University of Jerusalem, Israel
2010 – US-Israel Binational Science Foundation Grant  – collaboration with Prof. David G. Schatz, Yale School of Medicine, USA
2009 – EMBO short term fellowship – collaborative visit to Yale School of Medicine, USA
2007 – Wolf foundation award for outstanding Ph.D. students
2006 – Voted as outstanding teacher – ranked 1st among all Natural Sciences faculty teachers, Hebrew University, Israel
2005 – Luxemburg foundation prize for outstanding Masters students
2005 – Voted as outstanding teacher – ranked 2nd among all Natural Sciences faculty teachers, Hebrew University, Israel
2004 – Awarded B.Sc. summa cum laude. Final GPA 95.17 (out of 100)
2004- Top grade (100) for an undergraduate research project in biotechnology, Genetics Dept., Hebrew University, Israel
2003-4- “Amirim” program for outstanding natural sciences students – full tuition scholarship, Hebrew University, Israel
2003-4 – “Etgar” program for exceptional life sciences students, Hebrew University, Israel
2002 – Summer scholarship for excellent B.Sc. life sciences students,  Genetics Dept., Hebrew University, Israel
2002 – Dean’s Distinction for excellent students, Faculty of Natural Sciences, Hebrew University, Israel
2002 – Dean’s Honors list, Faculty of Natural Sciences, Hebrew University, Israel
Meet the Team

Key Publications

Replication-induced DNA secondary structures drive fork uncoupling and breakage

Sophie L Williams, Corella S Casas-Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma E Fletcher, Joseph TP Yeeles, Ulrich F Keyser, Zoe AE Waller, Marco Di Antonio and Gideon Coster
 EMBO J 2023
 Publisher  |  PubMed  |  PubMed Central

The Mechanism of Replication Stalling and Recovery within Repetitive DNA

Corella S Casas-Delucchi*, Manuel Daza-Martin*, Sophie L Williams and Gideon Coster (*Equal contribution)
 Nature Communications 2022
 Publisher  |  PubMed  |  PubMed Central

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

Gideon Coster, John FX Diffley
Science 2017
 Publisher  |  PubMed  |  PubMed Central
Highlighted by three F1000 Prime members as exceptional

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase

Gideon Coster, Jordi Frigola, Fabienne Beuron, Edward P Morris, John FX Diffley
Molecular Cell 2014
 Publisher  |  PubMed  |  PubMed Central
See all publications